Missy: [after drawing on Sheldon's face mask] So pretty.

George Sr.: What are you doing?
Missy: Watching Sheldon struggle with homework. It's so great.

Dale: So, how does this work?
Sheldon: You start by creating your character.
Missy: I want to be a Ninja Turtle Princess of Power.
Meemaw: Put me down for that, too.
Sheldon: You have to choose from one of the character classes. There's thief, druid, paladin, wizard...
Missy: Ooh, wizard. I want that.
Sheldon: All right.
Missy: Then I'll use my magic to turn me into a Ninja Turtle Princess of Power.
Sheldon: No.

Missy: So, this Dr. Lee is turning your friends against you?
Sheldon: Essentially.
Missy: Classic move. Most girls you find crying in the school bathroom, that was it.
Sheldon: What do I do?
Missy: Well, you're in a tough spot 'cause your personality is ugh.
Sheldon: There's enough people being mean to me right now.
Missy: Sorry.
Sheldon: Can you help me or not?
Missy: It's you against a bunch of college professors. I don't think you can win this one. [Sheldon starts to walk away] Oh. Do any of them have pimples?
Sheldon: No.
Missy: Too bad, I've done a lot of damage with "pizza face."

George Jr.: I think the saddest part about it is just how sad it is.

Adult Sheldon: As you can see, my meemaw successfully lured me back into the world by reminding me of my brave Texas ancestors. Their blood ran through my veins. I was a true son of the Lone Star State. Albeit a true son with an incredibly fragile immune system. I woke up the next morning with a temperature of 102 and a head packed full of mucus.

Meemaw: Mind if I take a crack at catching the Road Runner?
Mary: What are you gonna do that I couldn't do?
Meemaw: Oh, a little trick I learned trying to get prairie dogs out of the hole. Of course we'd whack off their heads with a golf club. I'm not gonna do that to Sheldon.