Missy: Sheldon, you went to a frat party; now there's a drunk girl in your bed. That's the coolest college story you'll ever get to tell.
Sheldon: So I can tell Mom.
Missy: No. Someday.
Sheldon: When?
Missy: Someday when we're old and we can laugh about it. I got to go. [Sheldon sighs]
Adult Sheldon: [v.o.] 30 years later, still not laughing.

Mary: Missy, if you want a minute with Dad before they close the casket, now's the time. [Missy looks unsure] It's okay if you don't.
Mary: I have to. [Missy stands up and walks up to her father's casket]
[flashback:]
George: Here, let me help you with that. Okay.
Missy: [eats] Holy moly.
George: It's good, huh?
Missy: Unbelievable.
George: I'll leave you to it.
Missy: No, sit with me.
George: Okay.
[present:]
Missy: [crying] Thank you for that. Thank you for everything. [sniffles] I love you.

Sheldon: Is Mom okay?
George: How the heck should I know?
Missy: She left. You can say "hell."

Dr. Sandra Thorpe: Have you always been that way?
Missy: I guess so. I think when you're on your own a lot, you get good at seeing that kind of stuff.
Dr. Sandra Thorpe: Really?
Missy: My dad does football with my older brother, so they're like a team. And my mom and meemaw spend all their time fussing over Sheldon, so they're like a team, too.
Dr. Sandra Thorpe: So no one's on your team?
Missy: Nope. It's just me.

Paige: I'm messing with you. It's just, sometimes life sucks, and it's easier not to deal with it.
Sheldon: Could you be more specific?
Paige: Um... well, I have no friends, I don't fit in anywhere, and I dropped out of college but I'm too young to get a job, so killing brain cells makes it easier.
Sheldon: Huh.
Paige: Go ahead, smart guy, fix me. [Sheldon is silent] Mm.
Sheldon: Well, give me a minute.

Georgie: You know what else is nice?
George: Hmm?
Georgie: I get to learn from all your parenting mistakes.
George: I'm starting to think letting you live this long was one of 'em.
Georgie: Like that. I'd never say something so awful to my kid. [George scoffs] Thanks, big guy.

Sheldon: What are you doing here?
Paige: Would you believe me if I told you I was working on a femtosecond laser in the engineering department?
Sheldon: Yes.
Paige: Then that.