Meemaw: And as far as your mom, I think things started to turn around for her when she gave birth to you.
Missy: You mean me and Sheldon.
Meemaw: No, I mean you. I mean, Sheldon was born fine, but you were a different story.
Missy: Why?
Meemaw: Okay. Well, there was a point where the doctors didn't know if you were gonna make it. And your mom got so scared, and she made a promise to God that if you were okay, that she would start reading the Bible, going to church you know, that kind of stuff.
Missy: So I'm the reason she's a dud?

George Sr.: What are you doing?
Missy: Watching Sheldon struggle with homework. It's so great.

Missy: So, this Dr. Lee is turning your friends against you?
Sheldon: Essentially.
Missy: Classic move. Most girls you find crying in the school bathroom, that was it.
Sheldon: What do I do?
Missy: Well, you're in a tough spot 'cause your personality is ugh.
Sheldon: There's enough people being mean to me right now.
Missy: Sorry.
Sheldon: Can you help me or not?
Missy: It's you against a bunch of college professors. I don't think you can win this one. [Sheldon starts to walk away] Oh. Do any of them have pimples?
Sheldon: No.
Missy: Too bad, I've done a lot of damage with "pizza face."

Mary: Bless us, Lord, for the food we are about to receive and bless the hands that prepared it.
Missy: And bless Mom.
Mary: Thank you. Amen.
Missy: Amen.
George Jr.: Amen.
Sheldon: She's the hands that prepared it. Your blessing is redundant.
Mary: Let's eat.

Tam: Look at this, my mother left me a note. "You can do better. Mom." Not "Love, Mom," not "XO, Mom," just "Mom."

Sheldon: Good news, I just spoke to Tommy Clarkson.
George Jr.: What? Are you crazy?
Sheldon: Nope, Mom had me tested.

Sheldon: Excuse me, sir. When you're done urinating, I'd like to ask you some questions about social dynamics, intimidation, threats, et cetera. Finish up, no hurry.