Mary: Lord, look after my son. Don't let him get stuffed in a gym bag.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Sheldon: And then they laughed at me for not knowing something that they knew. Who does that?
Mary: You do.
Sheldon: Well, this is no time for a teachable moment. Your child is hurting.
Mary: Sorry. [taps Sheldon's shoulder] There, there.
Sheldon: I guess that'll do. Now, how about a hot beverage?

Adult Sheldon: That was the first time I held my father's hand. I wouldn't touch my brother's hand until seventeen years later, thanks to the invention of Purell.

Mary: You understand that some people are going to be intimidated by you, because of how smart you are?
Sheldon: Or maybe they'll recognize my intellect and make me their leader.

Mary: How about we lose the bow-tie?
Sheldon: Why?
Mary: Look around, honey. No of the other kids are wearing one.
Sheldon: Well, perhaps I'll start a fad.