Georgie: Too bad he didn't know Herschel. He can fix anything. Guy's a genius.
George: You mean a car genius.
Missy: Is Dad getting his feelings hurt? "Yes." The ball don't lie.

Sheldon: While Dad's gone, I'm the man of the house, and the man of the house has to enforce the rules.
Missy: The man of the house is about to get his teeth knocked out.
Sheldon: Puberty's made you mean.
Missy: I need to know what happened on my show.
Sheldon: And you'll find out when your privileges are restored.
Missy: I can't wait that long, each episode builds on the last. Imagine a Star Trek that ends with "to be continued," and you don't get to continue.
Sheldon: That would never happen, because I follow the rules.
Missy: You are this close to a purple nurple.
Sheldon: [covers nipples] You leave my nurples alone.

Sheldon: Only 42 days until I go to Caltech.
Mary: That can't be right.
Missy: Oh, it is. It's in my calendar, too.
Mary: You don't have to be so excited about it.
Missy: It's a little late to pretend that I like him.

Mandy: Hey, uh, why don't we get out of here and do something?
Missy: Like what?
Mandy: I don't know, something fun.
Missy: Can we go to a bar?
Mandy: No.
Missy: Tattoo parlor?
Mandy: No.
Missy: Do you even know what fun is anymore?
Mandy: No.

Adult Sheldon: I've fought many digital battles in my life, but none are as memorable as this first one with my Meemaw. By handing me the controller, she was telling me she believed in me. That inside my small, fragile frame beat the heart of a hero.

Adult Sheldon: Even while sleeping, my quest to save the princess continued, which was quite a departure from my usual dreams, such as determining the coolest prime number Which, by the way, is 73.

Meemaw: I'm Sheldon Cooper's grandmother and, uh, I need to take him out of school today.
Diane: Sure. What's the reason?
Meemaw: His Aunt Emelda's not doing well, and has asked to see him 'fore she goes.
Diane: Oh, I am so sorry. Does she want to see his older brother also?
Meemaw: Nah. She doesn't like him as much.