Missy: I don't want to die. I've only kissed one boy so far.
Mary: What?
Missy: Relax. It was a long time ago.
George Sr.: Are you relaxed?

George Sr.: What are you doing?
Missy: Watching Sheldon struggle with homework. It's so great.

Mary: Bless us, Lord, for the food we are about to receive and bless the hands that prepared it.
Missy: And bless Mom.
Mary: Thank you. Amen.
Missy: Amen.
George Jr.: Amen.
Sheldon: She's the hands that prepared it. Your blessing is redundant.
Mary: Let's eat.

Missy: So, this Dr. Lee is turning your friends against you?
Sheldon: Essentially.
Missy: Classic move. Most girls you find crying in the school bathroom, that was it.
Sheldon: What do I do?
Missy: Well, you're in a tough spot 'cause your personality is ugh.
Sheldon: There's enough people being mean to me right now.
Missy: Sorry.
Sheldon: Can you help me or not?
Missy: It's you against a bunch of college professors. I don't think you can win this one. [Sheldon starts to walk away] Oh. Do any of them have pimples?
Sheldon: No.
Missy: Too bad, I've done a lot of damage with "pizza face."

George Sr.: Damn it. I've had enough of this. Sheldon, get up.
Sheldon: What's the point?
George Sr.: We're going to Houston.
Sheldon: Really?
George Sr.: Yeah. You and me are gonna give those space monkeys a little talkin' to.
Adult Sheldon: I often found my father to be a strange and puzzling man, but at that moment, I never loved him more.

Adult Sheldon: People often wonder why I chose to pursue a career in theoretical physics. I usually respond by saying I wanted to unravel the inner workings of the universe. But the real answer was I wanted to prove this nincompoop wrong.

George Jr.: Are you dyin'?
Meemaw: We're all dyin', honey. From the second we're born, it's just a slip and slide into the darkness.
George Jr.: Unless you get bit by a vampire.
Meemaw: Well, now that goes without saying.