Missy: You know this is your fault.
Sheldon: You're the one who read the letter.
Missy: You went in her nightstand.
Sheldon: I was only looking for a flashlight. It's not my fault Mom was hiding things there.
Missy: They're fighting 'cause you're a freak. That's your fault. You know I'm right.

George Sr.: What are you doing?
Missy: Watching Sheldon struggle with homework. It's so great.

Missy: So, this Dr. Lee is turning your friends against you?
Sheldon: Essentially.
Missy: Classic move. Most girls you find crying in the school bathroom, that was it.
Sheldon: What do I do?
Missy: Well, you're in a tough spot 'cause your personality is ugh.
Sheldon: There's enough people being mean to me right now.
Missy: Sorry.
Sheldon: Can you help me or not?
Missy: It's you against a bunch of college professors. I don't think you can win this one. [Sheldon starts to walk away] Oh. Do any of them have pimples?
Sheldon: No.
Missy: Too bad, I've done a lot of damage with "pizza face."

Mary: Bless us, Lord, for the food we are about to receive and bless the hands that prepared it.
Missy: And bless Mom.
Mary: Thank you. Amen.
Missy: Amen.
George Jr.: Amen.
Sheldon: She's the hands that prepared it. Your blessing is redundant.
Mary: Let's eat.

Mary: Shelly and this college stuff is killing me. I... I never went to college. How can I prepare him?
Brenda Sparks: Mary, if that kid is smart enough to have colleges wanting him already, he's got to be smart enough to figure it out.
Mary: Maybe. It still hurts to hear him say he wants to leave.
Brenda Sparks: I bet. On the other hand, I'm worried my Billy will never be ready to leave.
Mary: Oh, of course he will.
Brenda Sparks: Damn. Smoking, drinking, lying. You're covering all the sins today.

Mary: So, George is mad at me, and Sheldon is mad at me, and... honestly, I'm mad at me, too.
Brenda Sparks: Will you please give yourself a break? All that you do for that family, I am surprised you didn't crack years ago.
Mary: How do you handle it all?
Brenda Sparks: I'm sitting in a chicken coop drinking a wine cooler at 11:00 a.m.... clearly, I don't.

[on the "Why Sheldon Cooper Should Go to College" tape:]
Ms. Ingram: Honestly... teaching Sheldon is the hardest thing I've ever had to do. And I don't say that because he can be a pain. I say that because he's so intelligent, I had to study every night just to keep up. I'm gonna miss him.