501 - One Bad Night and Chaos of Selfish Desires
Aired Thursday, October 7, 2021

Sheldon and Missy both run away from home, and Mary gets upsetting news about George Sr.
- Guest Stars:
- Wallace Shawn as Dr. John Sturgis
- Melissa Peterman as Brenda Sparks
- Ava Allan as Jana
- Tom Yi as Dr. Kwok
- Writers (Story):
- Steve Holland
- Eric Kaplan
- Nick Bakay
- Writers (Teleplay):
- Steven Molaro
- Jeremy Howe
- Connor Kilpatrick
- Director:
- Alex Reid