George Sr.: Sheldon, I need to get in there.
Sheldon: Poop at Meemaw's!

Mary: See? Happy Hearth Home Bakeries, just like always.
Sheldon: Well, something is rotten in the state of Denmark.
Mary: What?
Sheldon: That's Shakespeare, Mom.
Mary: Great.

Sheldon: Uh-oh.
Missy: What?
Sheldon: Listen to this. "French philosopher, mathematician and physicist, Blaise Pascal, argued a rational person should believe God exists because you have everything to gain if you're right, and nothing to lose if you're wrong."
Missy: Sounds right.

Dr. Gilbert: So, those pain meds should already be kicking in. Then my buddy Gary here is gonna administer the gas, which'll help you sleep. And once you're under, we'll make a little incision and snatch that guy right outta there. Any questions?
Sheldon: Yes. What kind of doctor says, "Snatch that guy right out of there?"
Dr. Gilbert: Just trying to put you at ease.
Sheldon: It didn't work. Where did you go to medical school?
Dr. Gilbert: University of Nebraska.
Sheldon: Uh-oh. Did you at least graduate with honors?
Dr. Gilbert: Top of my class.
Sheldon: Have you had any alcohol in the last 24 hours?
Dr. Gilbert: Not a drop.
Sheldon: How much sleep did you get last-
Dr. Gilbert: Gary, can we-
Gary: Got it. Just relax and start counting backwards from 100.
Sheldon: Wait, Gary, where did you study anesthesiolo-

Mary: Everybody excited to start school Monday?
Sheldon: I am.
Missy: I guess so.
Mary: Georgie? Freshman year, that's a big deal.
George Jr.: How can I be excited when he's gonna be in the same grade as me?
Sheldon: Don't worry, Georgie. I'm not planning on being in the ninth grade for very long.

Tam: Is that any good?
Sheldon: I'm afraid not. I failed to make a single friend.
Tam: That sucks. I have a tough time making friends, too.
Sheldon: The worst part is, it was important to my mom.
Tam: My parents pressure me about making friends all the time.
Sheldon: So you understand what I'm going through.

George Sr.: Should we get started?
Malcolm Green: Yes.
Adult Sheldon: I realize some people may find the ins and outs of tax law a little tedious, so allow me to spice this story up. Instead of an audit, imagine this is a showdown between two warriors in the most brutal and exciting form of combat there is... chess. Am I the only one who just got chills?
[fantasy:]
Malcolm Green: Let's start with the business deductions from Schedule A on the tax return dated 1989.
Adult Sheldon: I know, bold opening move. Don't worry, I came to play.
Sheldon: Happy to. I've got those receipts right here. Dated, highlighted... and itemized.
Adult Sheldon: Told you. For the next three hours, we battled it out. Two mighty brains locked in mortal tax code combat.
Malcolm Green: Justify this expense.
Sheldon: Our AGI was less than $50,000.
Malcolm Green: Improper classification.
Sheldon: Rolled over from the previous fiscal year.
Malcolm Green: The receipt has barbecue sauce on it.
Sheldon: Dad.
George Sr.: Sorry.

Mr. Givens: All right. Well, I'll see you on Monday.
Sheldon: Wait. Would you like to sign my petition against Happy Hearth Home Bakeries?
Mr. Givens: Well, what have they done?
Sheldon: They're making their bread faster and cheaper to save money.
Mr. Givens: That's terrible.
Sheldon: It is. Would you like to sign?
Mr. Givens: I would.
Sheldon: Excellent.
Mr. Givens: I'll get you on the way out.
Sheldon: Thank you. Well, that's one.
Meemaw: Yeah.

Sheldon: I want to understand God. Can you help me?
One: Did you not hear what we just said?
Zero: It's a binary universe.
One: God is yes and no.
Zero: Left and right.
One: On and off.
Zero: Something and nothing.
One: Positive and negative.
Zero: Male and female.
One: Light and dark.
Sheldon: But why is there evil and suffering?
Zero: Well, without evil and suffering, there is no good and happiness.
Sheldon: Oh, sure. Binary.

Sam: This is so unfair. You get so much more than every other student.
Sheldon: Fair isn't everyone getting the same thing. Fair is everyone getting what they deserve.
Sam: Sheldon, that arrogant attitude is why no one sits with you in class or lunch or ever.
Sheldon: Well, I like to think that they're maintaining a respectful distance out of deference to my intellect.
Sam: No. That's not what they're doing. They're avoiding you because you're an entitled brat who thinks that you're better than everybody else.
Sheldon: So, I should just pretend I'm less intelligent than I am?
Sam: You should realize that there are more important things in life than how smart you are.
Sheldon: Well, I'm also cute as a button, but it seems shallow to say it. [an exasperated Sam walks away] You could say it.

Mary: Sheldon, who are you talking to?
Sheldon: Dorothy Fitzpatrick.
Mary: Who's Dorothy Fitzpatrick? Is she a new buddy from school?
Sheldon: She's the loan officer at The First National Bank of Medford.
Mary: Why are you talking to her?
Sheldon: Mom, can this wait? I'm trying to negotiate favorable terms. Hello, Dorothy? [Mary hangs up]

Nurse Robinson: Here you go. One O.J.
Sheldon: I see pulp.
Nurse Robinson: No, you don't. I strained it with a paper towel.
Sheldon: Now all I can taste is towel. And pulp.

Sheldon: You're sitting in my spot.
Tam: Why is it your spot?
Sheldon: It's complicated. Just move.

[Church board says "Jesus Exorcises Every Day."]
Sheldon: Did you write that?
Mary: You betcha.
Sheldon: Instead of puns, have you considered composing a humorous palindrome? It's a phrase that reads the same backwards as forwards. For example, "Do geese see God?" Trust me. Both ways.
Mary: Come inside.
Sheldon: Some other good ones are radar, level, kayak. That's a funny word. Kayak. Never get me in one.

Sheldon: [observing the older kids outside the high school] Oh dear.

Sheldon: I was exploring dimensional kinematics.
George Jr.: Admit it. He's adopted.
Sheldon: How can I be adopted when I have a twin sister? Think, monkey, think.

Sheldon: So none of you can help me?
Albert Einstein: I believe I can. Sheldon, if I was offered a choice between all the knowledge of the universe or the endless pursuit of it, I would choose the pursuit.
Sheldon: That's very insightful.
Richard Feynman: Hold it, hold it... He didn't come up with that! He stole it from Gotthold Lessing.
Professor Proton: Who's-who's Gotthold Lessing?
Cyndi Lauper: [v.o.] He's an 18th century German philosopher. Now do you mind? We girls are trying to have some fun over here.
Einstein: Apologies.
Richard Feynman: Sorry, Cyndi Lauper.
Stephen Hawking: Our bad.
Professor Proton: I-I like fun.

Ms. Fenley: You have perfect pitch.
Sheldon: Okay.
Ms. Fenley: Sweetheart, you should really pursue music.
Sheldon: No, thank you. Musicians take drugs. Is there a faculty restroom I could use?

Sheldon: Now we need to put in a name before we start.
Meemaw: What are you thinking?
Sheldon: We should combine the letters in our two names, Sheldon and Meemaw.
Meemaw: Like, uh, ShelMaw?
Sheldon: No, using all the letters, like Emelda Showmen.
Meemaw: Did you just do that in your head?
Sheldon: Yes, why?
Meemaw: Never mind, just put it down.

Sheldon: [on the phone] Hello, First National Bank. I'd like to speak with a loan officer. It's regarding a second mortgage on my home. My name is Sheldon Lee Cooper. Sure, I'll hold. Oh, I hate hold music.