Meemaw: You were saying?
Mary: I was just thinking about when I was pregnant with Georgie, and... how hard that must've been for you. I'm sorry.
Meemaw: Georgie got that girl pregnant?!
Mary: Keep your voice down. And... yes.
Meemaw: Oh...

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

George Sr.: You ever stop to think maybe she doesn't want to marry a 17-year-old?
Mary: He'll be 18 in March.
George Sr.: All right, you're just being ridiculous. [goes back inside]
Mary: I'm being a Christian.
[After Mary walks over and knocks on the garage door, a dozy Georgie opens it]
Mary: When you were born, you were a gift from God but that does not change the fact that I am very mad at you!
George Jr.: All right. [closes door]

Mary: When do we get to sit down with her and talk this through?
George Jr.: Ah, yeah, here's the thing about that: she ain't real eager to meet y'all.
Mary: Why not?
Meemaw: Did you want to meet George's parents when he knocked you up?
Mary: I was not "knocked up," I was with child. And he's right there. [Georgie waves to Meemaw]

George Jr.: Okay, in my defense...
Meemaw: You have no defense. You're an idiot.
George Jr.: That was a big part of my defense.