Meemaw: I mean, I'm worried about him. I don't know how serious this is.
Mary: The whole year you were together did you see any, um warning signs?
Meemaw: No. Not really. I just thought he was another, [chuckles] you know, cute, quirky egghead like Sheldon. Speaking of which, when are you gonna tell Sheldon the truth about John?
Mary: Mm. When the time is right.
Meemaw: So he still thinks he's being treated for mono?
Mary: I had to come up with something contagious so he wouldn't want to visit.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Mary: I was just letting you know that if you were having any problems you could come to me with them.
Sheldon: You think I have mental problems?
Mary: Well, not problems. I'm just worried about your future, and when I see you moving subatomic particles around in the air, that makes-
Sheldon: Subatomic particles are real! You talk to an invisible man in the sky who grants wishes. If anyone's mental, it's you.

Sheldon: My mother believes I'm mentally unstable. And since there's a genetic component and I'm her child, I suppose it's possible.
Mary: I know you're angry right now, but you will not be disrespectful.
Sheldon: You know, fits of rage are a classic sign of psychosis.
Mary: Oh, you haven't seen fits of rage yet!

Meemaw: Smart.
Mary: Thank you.
Meemaw: You're good at lying. You should do it more often.
Mary: I like your earrings.